Sugi Predict

Sugi Predict / Compounds / SCHEMBL23516675

SCHEMBL23516675

SCHEMBL23516675

CCn1cc2c(c1C(=O)Nc1ccc(F)c(Cl)c1)CCC2NC(=O)OCc1ncn(C)n1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ MAOA P21397 2/20 0.37
▸ MAOB P27338 2/20 0.37
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ SLC10A1 Q14973 5/20 0.34
▸ MALT1 Q9UDY8 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ PDE10A Q9Y233 1/20 0.34
▸ THRB P10828 2/20 0.33
▸ TSHR P16473 1/20 0.33
▸ SCD O00767 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ EGFR P00533 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30359978 0.92 MAOA (0.39) MAPTNPC1LMNARAB9AMAOA
SCHEMBL23516682 0.92 MAOA (0.39) MAPTNPC1LMNARAB9AMAOA
SCHEMBL23516676 0.88 MAPT (0.40) MAPTNPC1LMNARAB9AMAOA
SCHEMBL23516551 0.88 MAOA (0.38) MAPTNPC1LMNARAB9AMAOA
SCHEMBL23516647 0.87 MAOA (0.37) MAPTNPC1LMNARAB9AMAOA
SCHEMBL23516604 0.85 MEN1 (0.37) MAPTNPC1LMNARAB9AMAOA
SCHEMBL23496601 0.85 MAOA (0.37) MAPTNPC1LMNARAB9AMAOA
SCHEMBL23516874 0.84 MAOA (0.37) MAPTNPC1LMNARAB9AMAOA
SCHEMBL30359993 0.84 MAOA (0.37) MAPTNPC1LMNARAB9AMAOA
SCHEMBL23516602 0.84 CYP11B2 (0.35) NPC1LMNARAB9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11566002-B2 Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same ARBUTUS BIOPHARMA CORPORATION (CA) 2023-01-31 — — US claimed
US-11566002-B2 Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same ARBUTUS BIOPHARMA CORPORATION (CA) 2023-01-31 — — US disclosed
US-11566002-B2 Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same ARBUTUS BIOPHARMA CORPORATION (CA) 2023-01-31 — — US disclosed
US-20210179557-A1 SUBSTITUTED TETRAHYDROCYCLOPENTA[C]PYRROLES, SUBSTITUTED DIHYDROPYRROLIZINES, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2021-06-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210179557-A1 SUBSTITUTED TETRAHYDROCYCLOPENTA[C]PYRROLES, SUBSTITUTED DIHYDROPYRROLIZINES, ANALOGUES THEREOF, AND METHODS USING SAME DHPS, HMBS, HAVCR2 MAPT 2409/4885NPC1 667/4885LMNA 2415/4885
US-11566002-B2 Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same DHPS, HMBS, HAVCR2 MAPT 2409/4885NPC1 667/4885LMNA 2415/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.