Sugi Predict

Sugi Predict / Compounds / SCHEMBL23516682

SCHEMBL23516682

SCHEMBL23516682

Cn1cnc(COC(=O)NC2CCc3c2cn(C)c3C(=O)Nc2ccc(F)c(Cl)c2)n1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 2/20 0.39
▸ MAOB P27338 2/20 0.39
▸ MAPT P10636 3/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ MALT1 Q9UDY8 1/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ SLC10A1 Q14973 5/20 0.35
▸ THRB P10828 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ KCNJ6 P48051 1/20 0.34
▸ KCNJ5 P48544 1/20 0.34
▸ KCNJ3 P48549 1/20 0.34
▸ CHRM3 P20309 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30359978 1.00 MAOA (0.39) MAOAMAOBMAPTNPC1LMNA
SCHEMBL23516551 0.96 MAOA (0.38) MAOAMAOBMAPTNPC1LMNA
SCHEMBL23516647 0.95 MAOA (0.37) MAOAMAOBMAPTNPC1LMNA
SCHEMBL23516604 0.93 MEN1 (0.37) MAOAMAOBMAPTNPC1LMNA
SCHEMBL23516675 0.92 MAPT (0.39) MAOAMAOBMAPTNPC1LMNA
SCHEMBL30359987 0.92 CYP11B2 (0.35) NPC1LMNARAB9AMEN1KMT2A
SCHEMBL23516602 0.92 CYP11B2 (0.35) NPC1LMNARAB9AMEN1KMT2A
SCHEMBL23516595 0.90 SLC10A1 (0.33) NPC1RAB9AMEN1KMT2ASLC10A1
SCHEMBL23516842 0.90 GRM4 (0.36) THRBCHRM3
SCHEMBL23516585 0.90 GRM4 (0.37) SLC10A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11566002-B2 Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same ARBUTUS BIOPHARMA CORPORATION (CA) 2023-01-31 — — US claimed
US-11566002-B2 Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same ARBUTUS BIOPHARMA CORPORATION (CA) 2023-01-31 — — US disclosed
US-11566002-B2 Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same ARBUTUS BIOPHARMA CORPORATION (CA) 2023-01-31 — — US disclosed
US-20210179557-A1 SUBSTITUTED TETRAHYDROCYCLOPENTA[C]PYRROLES, SUBSTITUTED DIHYDROPYRROLIZINES, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2021-06-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210179557-A1 SUBSTITUTED TETRAHYDROCYCLOPENTA[C]PYRROLES, SUBSTITUTED DIHYDROPYRROLIZINES, ANALOGUES THEREOF, AND METHODS USING SAME DHPS, HMBS, HAVCR2 MAOA 3145/4885MAOB 2722/4885MAPT 2409/4885
US-11566002-B2 Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same DHPS, HMBS, HAVCR2 MAOA 3145/4885MAOB 2722/4885MAPT 2409/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.