Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536098 | 0.85 | TP53 (0.44) | TP53SMN1; SMN2ALDH1A1KDM4ENPSR1 | |
| SCHEMBL23536308 | 0.81 | TP53 (0.42) | TP53SMN1; SMN2ALDH1A1KDM4ENPSR1 | |
| SCHEMBL23536231 | 0.81 | POLB (0.59) | TP53SMN1; SMN2ALDH1A1CYP2C19POLB | |
| SCHEMBL23536339 | 0.76 | ALDH1A1 (0.40) | TP53SMN1; SMN2ALDH1A1KDM4ENPSR1 | |
| SCHEMBL23536283 | 0.71 | MCOLN2 (0.44) | TP53SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL12127791 | 0.71 | SMN1; SMN2 (0.48) | TP53SMN1; SMN2ALDH1A1KDM4ENPSR1 | |
| SCHEMBL23582982 | 0.70 | CYP2C19 (0.46) | KDM4ENPSR1USP2HPGDHSD17B10 | |
| SCHEMBL3788594 | 0.70 | KDM4E (0.62) | TP53SMN1; SMN2ALDH1A1KDM4ENPSR1 | |
| SCHEMBL6204089 | 0.69 | ALDH1A1 (0.61) | TP53SMN1; SMN2ALDH1A1KDM4ENPSR1 | |
| SCHEMBL6501087 | 0.68 | NOTUM (0.57) | TP53SMN1; SMN2ALDH1A1KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |