Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GPR174 | Q9BXC1 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.41 |
| ▸ | RHOA | P61586 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536098 | 0.81 | TP53 (0.44) | POLBCYP2C9CYP2C19ALDH1A1TP53 | |
| SCHEMBL23536173 | 0.81 | TP53 (0.44) | POLBCYP2C9CYP2C19ALDH1A1TP53 | |
| SCHEMBL23536308 | 0.78 | TP53 (0.42) | POLBCYP2C9CYP2C19ALDH1A1TP53 | |
| SCHEMBL30977058 | 0.73 | MAPT (0.50) | POLBCYP2C9CYP2C19TDP1MAPT | |
| SCHEMBL23536339 | 0.72 | ALDH1A1 (0.40) | POLBCYP2C9CYP2C19ALDH1A1TP53 | |
| SCHEMBL6501188 | 0.70 | TDP1 (0.60) | POLBCYP2C9CYP2C19TDP1MAPT | |
| SCHEMBL23536283 | 0.70 | MCOLN2 (0.44) | MAPTALDH1A1TP53SMN1; SMN2KMT2A | |
| SCHEMBL4403596 | 0.69 | TDP1 (0.74) | POLBCYP2C9CYP2C19TDP1MAPT | |
| SCHEMBL2559246 | 0.69 | TDP1 (0.63) | POLBCYP2C9CYP2C19TDP1MAPT | |
| SCHEMBL23536097 | 0.68 | MAPT (0.58) | POLBTDP1MAPTALDH1A1GPR174 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |