Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 12/20 | 0.35 |
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536308 | 0.84 | TP53 (0.42) | ALDH1A1TP53SMN1; SMN2FFAR4NEK2 | |
| SCHEMBL23536018 | 0.76 | ALDH1A1 (0.42) | ALDH1A1TP53SMN1; SMN2FFAR4KDM4E | |
| SCHEMBL23536098 | 0.76 | TP53 (0.44) | ALDH1A1TP53SMN1; SMN2FFAR4NEK2 | |
| SCHEMBL23536173 | 0.76 | TP53 (0.44) | ALDH1A1TP53SMN1; SMN2FFAR4KDM4E | |
| SCHEMBL23536231 | 0.72 | POLB (0.59) | ALDH1A1TP53SMN1; SMN2CYP2C19POLB | |
| SCHEMBL23536283 | 0.67 | MCOLN2 (0.44) | ALDH1A1TP53SMN1; SMN2KDM4EHPGD | |
| SCHEMBL12127791 | 0.63 | SMN1; SMN2 (0.48) | ALDH1A1TP53SMN1; SMN2FFAR4KDM4E | |
| SCHEMBL27176755 | 0.63 | KDM4E (0.43) | ALDH1A1KDM4EUSP2 | |
| SCHEMBL23582982 | 0.62 | CYP2C19 (0.46) | FFAR4NEK2KDM4EUSP2HPGD | |
| SCHEMBL3788594 | 0.62 | KDM4E (0.62) | ALDH1A1TP53SMN1; SMN2NEK2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |