Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19001342 | 0.90 | MAPK1 (0.55) | LMNAMAPK1ALDH1A1HTTCASP3 | |
| SCHEMBL23535999 | 0.86 | SIGMAR1 (0.51) | LMNAALDH1A1HTTCASP3TDP1 | |
| SCHEMBL23536311 | 0.85 | CASP3 (0.46) | LMNAMAPK1ALDH1A1HTTCASP3 | |
| SCHEMBL29948505 | 0.85 | CA2 (0.50) | LMNAALDH1A1HTTCASP3CDK1 | |
| SCHEMBL21565813 | 0.84 | ALDH1A1 (0.53) | LMNAMAPK1ALDH1A1HTTCCR5 | |
| SCHEMBL23536539 | 0.80 | CASP3 (0.43) | LMNAMAPK1ALDH1A1HTTCASP3 | |
| Lithium Ion SCHEMBL28867464 | 0.80 | CASP3 (0.43) | LMNAMAPK1ALDH1A1HTTCASP3 | |
| SCHEMBL5128119 | 0.80 | ALDH1A1 (0.55) | LMNAMAPK1ALDH1A1HTTCCR5 | |
| SCHEMBL21169198 | 0.80 | LMNA (0.49) | LMNAMAPK1ALDH1A1HTTNR1I2 | |
| SCHEMBL28867383 | 0.80 | TDP1 (0.43) | LMNAALDH1A1HTTCASP3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |