Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536152 | 0.90 | LMNA (0.40) | MAPTNPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL29931786 | 0.90 | LMNA (0.40) | MAPTNPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL29932096 | 0.81 | ALDH1A1 (0.40) | LMNAALDH1A1HTTTHRBNPSR1 | |
| SCHEMBL29932238 | 0.77 | LMNA (0.38) | LMNAALDH1A1HTTTHRBNPSR1 | |
| SCHEMBL23536015 | 0.77 | PAX8 (0.37) | MAPTLMNAL3MBTL1THRBKDM4E | |
| SCHEMBL23536063 | 0.76 | CXCR4 (0.47) | MAPTLMNAALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL23536124 | 0.76 | TSHR (0.39) | LMNAALDH1A1HTTL3MBTL1THRB | |
| SCHEMBL29931867 | 0.76 | TSHR (0.39) | LMNAALDH1A1HTTL3MBTL1THRB | |
| SCHEMBL23536515 | 0.72 | MEN1 (0.34) | LMNAL3MBTL1MEN1KDM4EPAX8 | |
| SCHEMBL23536136 | 0.72 | TSHR (0.38) | MAPTLMNAALDH1A1HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |