Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536515 | 0.82 | MEN1 (0.34) | PAX8MCOLN2RORCLMNAKDM4E | |
| SCHEMBL29948512 | 0.79 | MCOLN2 (0.56) | PAX8MCOLN2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29931917 | 0.78 | MCOLN2 (0.35) | PAX8MCOLN2RORCCYP3A4CYP2C9 | |
| SCHEMBL23536202 | 0.77 | MAPT (0.40) | PAX8MAPTLMNATHRBKDM4E | |
| SCHEMBL23536277 | 0.77 | GPR119 (0.36) | PAX8MCOLN2RORC | |
| SCHEMBL29931763 | 0.74 | PAX8 (0.36) | PAX8MCOLN2CYP3A4HTR2AHTR2C | |
| SCHEMBL23536497 | 0.74 | PAX8 (0.36) | PAX8MCOLN2CYP3A4HTR2AHTR2C | |
| SCHEMBL29031114 | 0.72 | KDM4E (0.39) | C5AR1KDM4E | |
| SCHEMBL23536018 | 0.72 | ALDH1A1 (0.42) | PAX8RORCHTR2AHTR2CLMNA | |
| SCHEMBL23536045 | 0.70 | ALDH1A1 (0.32) | LMNAC5AR1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |