Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931897 | 1.00 | CTSB (0.49) | CTSBCYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL23536471 | 0.84 | HTT (0.48) | CTSBALDH1A1KMT2AHTTMAPT | |
| SCHEMBL29948611 | 0.84 | HTT (0.48) | CTSBALDH1A1KMT2AHTTMAPT | |
| SCHEMBL30779614 | 0.82 | CTSB (0.68) | CTSBCYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL2206983 | 0.82 | CTSB (0.68) | CTSBCYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL29931922 | 0.82 | ALDH1A1 (0.47) | ALDH1A1KMT2AHTTMAPTLMNA | |
| SCHEMBL23536258 | 0.82 | ALDH1A1 (0.47) | ALDH1A1KMT2AHTTMAPTLMNA | |
| SCHEMBL3435490 | 0.81 | CTSB (0.52) | CTSBCYP1A2ALDH1A1KMT2AMEN1 | |
| SCHEMBL4939842 | 0.80 | ALDH1A1 (0.56) | CYP2C19ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL28241 | 0.79 | KMT2A (0.60) | ALDH1A1KMT2AMEN1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |