Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931958 | 0.83 | DRD4 (0.38) | ALDH1A1DRD4GRM2PROKR1PHGDH | |
| SCHEMBL23536237 | 0.83 | DRD4 (0.38) | ALDH1A1DRD4GRM2PROKR1PHGDH | |
| SCHEMBL29932053 | 0.79 | RPS6KB1 (0.45) | ALDH1A1MAPTKMT2ALMNARPS6KB1 | |
| SCHEMBL23536271 | 0.79 | RPS6KB1 (0.45) | ALDH1A1MAPTKMT2ALMNARPS6KB1 | |
| SCHEMBL29932049 | 0.77 | PHGDH (0.39) | MAPTKMT2ALMNADRD4GRM2 | |
| SCHEMBL23536190 | 0.77 | PHGDH (0.39) | MAPTKMT2ALMNADRD4GRM2 | |
| SCHEMBL29932109 | 0.76 | MAPT (0.37) | ALDH1A1MAPTKMT2ALMNAPROKR1 | |
| SCHEMBL23536527 | 0.75 | ALDH1A1 (0.44) | ALDH1A1MAPTKMT2ALMNAMAPK1 | |
| SCHEMBL29931935 | 0.75 | ALDH1A1 (0.44) | ALDH1A1MAPTKMT2ALMNAMAPK1 | |
| SCHEMBL29932026 | 0.74 | SIGMAR1 (0.36) | DRD4GRM2PROKR1PHGDHFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |