Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932049 | 1.00 | PHGDH (0.39) | PHGDHTRPV1MEN1KMT2ASIGMAR1 | |
| SCHEMBL29932026 | 0.81 | SIGMAR1 (0.36) | PHGDHTRPV1SIGMAR1DRD4GRM2 | |
| SCHEMBL29931958 | 0.79 | DRD4 (0.38) | PHGDHTRPV1SIGMAR1DRD4GRM2 | |
| SCHEMBL23536237 | 0.79 | DRD4 (0.38) | PHGDHTRPV1SIGMAR1DRD4GRM2 | |
| SCHEMBL29932124 | 0.79 | PHGDH (0.42) | PHGDHMEN1KMT2AHTTPROKR1 | |
| SCHEMBL23536493 | 0.79 | PHGDH (0.42) | PHGDHMEN1KMT2AHTTPROKR1 | |
| SCHEMBL23536369 | 0.77 | ALDH1A1 (0.38) | PHGDHMEN1KMT2ADRD4GRM2 | |
| SCHEMBL29932109 | 0.73 | MAPT (0.37) | MEN1KMT2AHTTCYP3A4CYP2C9 | |
| SCHEMBL29931836 | 0.71 | GAA (0.34) | KMT2AHTTDRD4GRM2PROKR1 | |
| SCHEMBL23536396 | 0.64 | ALDH1A1 (0.39) | TRPV1SIGMAR1HTTDRD4GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |