Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 9/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.51 |
| ▸ | FEN1 | P39748 | 4/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1079862 | 0.83 | GABRG2 (0.58) | GABRG2GABRB3GABRA5GABRA3FEN1 | |
| SCHEMBL6019107 | 0.80 | CYP1A2 (0.45) | FEN1ALOX5APALDH1A1L3MBTL1ADORA2A | |
| SCHEMBL2648964 | 0.75 | GABRG2 (0.52) | GABRG2GABRB3GABRA5GABRA3FEN1 | |
| SCHEMBL15636423 | 0.74 | GABRG2 (0.44) | GABRG2GABRB3GABRA5GABRA3FEN1 | |
| SCHEMBL23607649 | 0.74 | GABRG2 (0.38) | GABRG2GABRB3GABRA5GABRA3FEN1 | |
| SCHEMBL15624387 | 0.73 | GABRG2 (0.43) | GABRG2GABRB3GABRA5GABRA3FEN1 | |
| SCHEMBL1923848 | 0.72 | GABRG2 (0.40) | GABRG2GABRB3GABRA5GABRA3FEN1 | |
| SCHEMBL23536042 | 0.72 | ALDH1A1 (0.45) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL29931945 | 0.72 | ALDH1A1 (0.45) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL25216814 | 0.71 | GABRG2 (0.46) | GABRG2GABRB3GABRA5GABRA3FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230104936-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-04-06 | — | — | US | disclosed |
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230104936-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | GABRG2 817/4885GABRB3 528/4885GABRA5 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.