Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 10/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.49 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536381 | 0.83 | GABRG2 (0.51) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL15636423 | 0.78 | GABRG2 (0.44) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL15624387 | 0.78 | GABRG2 (0.43) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2654021 | 0.78 | GABRG2 (0.42) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL29931945 | 0.77 | ALDH1A1 (0.45) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL23536042 | 0.77 | ALDH1A1 (0.45) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652324 | 0.76 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL1066139 | 0.76 | GABRG2 (0.52) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2648964 | 0.76 | GABRG2 (0.52) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL15637566 | 0.75 | GABRG2 (0.42) | GABRG2GABRB3GABRA5GABRA3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456311-A1 | SUBSTITUTED IMIDAZOTRIAZINES | Concert Pharmaceuticals Inc. (US) | 2012-05-30 | — | — | EP | disclosed |
| US-20110082147-A1 | SUBSTITUTED IMIDAZOTRIAZINES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | US | disclosed |
| US-20110082147-A1 | SUBSTITUTED IMIDAZOTRIAZINES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | US | disclosed |
| US-20110082147-A1 | SUBSTITUTED IMIDAZOTRIAZINES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | US | disclosed |
| WO-2011011712-A1 | SUBSTITUTED IMIDAZOTRIAZINES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011011712-A1 | SUBSTITUTED IMIDAZOTRIAZINES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082147-A1 | SUBSTITUTED IMIDAZOTRIAZINES | GABRA5, GABRA3, GABRA2 | GABRG2 15/4885GABRB3 5/4885GABRA5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.