Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.39 |
| ▸ | PTGFR | P43088 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536654 | 0.83 | SCN5A (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23536676 | 0.81 | HTR6 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23536553 | 0.81 | MAPT (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23536607 | 0.73 | HTR6 (0.44) | CCR1 | |
| SCHEMBL23536755 | 0.71 | CCR1 (0.43) | CCR1RORC | |
| SCHEMBL23536641 | 0.69 | HTT (0.46) | CYP2C19 | |
| SCHEMBL29836123 | 0.69 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3SCN9AKCNH2 | |
| SCHEMBL28364292 | 0.69 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3SCN9AKCNH2 | |
| SCHEMBL23536620 | 0.68 | HTR6 (0.49) | — | |
| SCHEMBL23536590 | 0.67 | MEN1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |