Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.44 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797697 | 0.84 | HTR6 (0.59) | HTR6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL23536755 | 0.76 | CCR1 (0.43) | HTR6CCR1LMNASMN1; SMN2HTT | |
| SCHEMBL23536676 | 0.76 | HTR6 (0.38) | HTR6CCR1LMNASMN1; SMN2HTT | |
| SCHEMBL21624028 | 0.76 | NPC1 (0.40) | HTR6NPC1RAB9A | |
| SCHEMBL30559970 | 0.76 | NPC1 (0.40) | HTR6NPC1RAB9A | |
| SCHEMBL23536654 | 0.75 | SCN5A (0.38) | HTR6CCR1LMNASMN1; SMN2HTT | |
| SCHEMBL23536553 | 0.73 | MAPT (0.38) | HTR6CCR1MAPTLMNAALDH1A1 | |
| SCHEMBL23536574 | 0.73 | SLC6A2 (0.40) | CCR1 | |
| SCHEMBL23536713 | 0.71 | CYP2C19 (0.41) | HTR6MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL27087160 | 0.69 | SLC9A1 (0.42) | HTR6MAPTLMNAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |