Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 4/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536676 | 0.90 | HTR6 (0.38) | CYP2C19PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23536553 | 0.83 | MAPT (0.38) | CYP2C19PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23536574 | 0.83 | SLC6A2 (0.40) | SCN9ACYP2C19PSEN1PSEN2APH1B | |
| SCHEMBL23536744 | 0.78 | ALDH3A1 (0.46) | SCN5ASCN9APSEN1PSEN2APH1B | |
| SCHEMBL23536620 | 0.76 | HTR6 (0.49) | HTR6CYP3A4 | |
| SCHEMBL23536607 | 0.75 | HTR6 (0.44) | HTR6CCR1LMNAHTTSMN1; SMN2 | |
| SCHEMBL23536755 | 0.71 | CCR1 (0.43) | HTR6CCR1RORCLMNATP53 | |
| SCHEMBL23536641 | 0.71 | HTT (0.46) | CYP2C19HTR6LMNATP53GAA | |
| SCHEMBL23536713 | 0.67 | CYP2C19 (0.41) | CYP2C19HTR6LOXL2LMNATP53 | |
| SCHEMBL23569703 | 0.66 | HTR6 (0.57) | HTR6HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |