Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.53 |
| ▸ | METAP2 | P50579 | 4/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 6/20 | 0.41 |
| ▸ | RAF1 | P04049 | 5/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28198038 | 0.77 | METAP2 (0.64) | NOS1METAP2BRD4AXLIDO1 | |
| SCHEMBL31299391 | 0.74 | METAP2 (0.53) | NOS1METAP2AXLIDO1TRPA1 | |
| SCHEMBL14737953 | 0.74 | METAP2 (0.53) | NOS1METAP2AXLIDO1TRPA1 | |
| SCHEMBL30469214 | 0.74 | AXL (0.63) | NOS1METAP2BRD4AXLIDO1 | |
| SCHEMBL5951586 | 0.74 | AXL (0.63) | NOS1METAP2BRD4AXLIDO1 | |
| SCHEMBL23536668 | 0.73 | ROCK2 (0.49) | NOS1AXLBRAFRAF1TRPA1 | |
| SCHEMBL23520254 | 0.72 | METAP2 (0.49) | NOS1METAP2BRD4AXLIDO1 | |
| SCHEMBL14631290 | 0.71 | NOS1 (0.50) | NOS1METAP2AXLIDO1BRAF | |
| SCHEMBL31178711 | 0.70 | CSF1R (0.57) | NOS1METAP2 | |
| SCHEMBL476854 | 0.70 | NOS1 (1.00) | NOS1METAP2AXLIDO1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |