Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.32 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536536 | 0.66 | HSD11B1 (0.40) | HSD11B1PDE4AALDH1A1MAPTHTT | |
| SCHEMBL23536626 | 0.66 | HSD11B1 (0.46) | HSD11B1ALDH1A1HTTSMN1; SMN2GBA1 | |
| SCHEMBL31713550 | 0.66 | GAA (0.40) | HSD11B1GPR119L3MBTL1ALDH1A1MAPT | |
| SCHEMBL31190677 | 0.64 | HSD11B1 (0.42) | HSD11B1MAPTPOLBSLC9A1 | |
| SCHEMBL31190587 | 0.64 | HSD11B1 (0.42) | HSD11B1MAPTPOLBSLC9A1 | |
| SCHEMBL31713426 | 0.64 | HSD11B1 (0.41) | HSD11B1GPR119ALDH1A1HTTPOLB | |
| SCHEMBL23570345 | 0.64 | ALDH1A1 (0.44) | HSD11B1L3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL22578963 | 0.64 | DRD4 (0.43) | GPR119MAPTSMN1; SMN2PDE10A | |
| SCHEMBL23536541 | 0.63 | RORC (0.37) | HSD11B1PDE4AMAPTRORC | |
| SCHEMBL23570175 | 0.63 | HTR6 (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |