Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 4/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA4 | P22748 | 2/20 | 0.51 |
| ▸ | CA6 | P23280 | 2/20 | 0.51 |
| ▸ | CA5A | P35218 | 2/20 | 0.51 |
| ▸ | CA7 | P43166 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.51 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23582737 | 1.00 | AKR1B10 (0.51) | AKR1B10AKR1B1CA12CA4CA6 | |
| SCHEMBL23599635 | 0.82 | CYP1A2 (0.35) | AKR1B10AKR1B1CA12CA4CA6 | |
| SCHEMBL15910890 | 0.80 | LMNA (0.54) | AKR1B10AKR1B1CA12CA4CA6 | |
| SCHEMBL23876186 | 0.77 | NPC1 (0.49) | LMNAALDH1A1 | |
| SCHEMBL228601 | 0.77 | NR4A2 (0.51) | LMNAMAOBALDH1A1 | |
| SCHEMBL3045824 | 0.77 | ALDH1A1 (0.49) | ALDH1A1 | |
| SCHEMBL23876180 | 0.77 | KMT2A (0.50) | LMNAALDH1A1 | |
| SCHEMBL25300422 | 0.77 | PTPN1 (0.46) | NR1H2ALDH1A1 | |
| SCHEMBL9743395 | 0.76 | LMNA (0.73) | AKR1B10AKR1B1CA12CA4CA6 | |
| SCHEMBL9743400 | 0.76 | LMNA (0.73) | AKR1B10AKR1B1CA12CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901653-A | Novel amide derivatives useful as diacylglycerol acyltransferase 2 inhibitors and uses thereof | 株式会社LG化学 | 2022-08-12 | — | — | CN | disclosed |
| WO-2021133038-A1 | NOVEL AMIDE DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF | 주식회사 엘지화학 | 2021-07-01 | — | — | WO | disclosed |