SCHEMBL23588315

SCHEMBL23588315

C=C(Cc1nc(-c2ccc(OCCCOC)cc2)no1)C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 3/20 0.50
▸ MITF O75030 1/20 0.50
▸ NCOA3 Q9Y6Q9 1/20 0.50
▸ LMNA P02545 2/20 0.49
▸ ATM Q13315 1/20 0.49
▸ ACACB O00763 1/20 0.49
▸ ACACA Q13085 1/20 0.49
▸ HPGD P15428 2/20 0.47
▸ L3MBTL1 Q9Y468 2/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ FFAR1 O14842 2/20 0.45
▸ MAPT P10636 2/20 0.45
▸ TSHR P16473 1/20 0.45
▸ PPARD Q03181 1/20 0.45
▸ PPARA Q07869 1/20 0.45
▸ HDAC1 Q13547 2/20 0.43
▸ GSTP1 P09211 1/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ HDAC2 Q92769 1/20 0.43
▸ HDAC8 Q9BY41 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23578433 0.91 ACACB (0.57) TP53MITFNCOA3LMNAATM
SCHEMBL23578438 0.89 ACACB (0.64) TP53MITFNCOA3LMNAATM
SCHEMBL23588220 0.85 FFAR1 (0.46) TP53MITFNCOA3LMNAATM
SCHEMBL30880252 0.81 ACACB (0.56) TP53MITFNCOA3LMNAATM
SCHEMBL23578031 0.81 FFAR1 (0.56) L3MBTL1TDP1FFAR1TSHRPPARD
SCHEMBL25802136 0.80 MAPT (0.53) LMNAATMHPGDL3MBTL1TDP1
SCHEMBL30689396 0.79 LMNA (0.46) TP53MITFNCOA3LMNAATM
SCHEMBL30689438 0.79 LMNA (0.51) TP53MITFNCOA3LMNAATM
SCHEMBL31527827 0.79 TP53 (0.46) TP53MITFNCOA3LMNAATM
SCHEMBL27291369 0.78 MITF (0.43) TP53MITFNCOA3LMNAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115066418-A Carboxy derivatives with anti-inflammatory properties 西特瑞治疗有限公司 2022-09-16 — — CN claimed
US-12617762-B2 Carboxy derivatives with antiinflamatory properties SITRYX THERAPEUTICS LIMITED (GB) 2026-05-05 — — US disclosed
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2023-07-13 — — US disclosed
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2023-07-13 — — US disclosed
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2023-07-13 — — US disclosed
CN-115066418-A Carboxy derivatives with anti-inflammatory properties 西特瑞治疗有限公司 2022-09-16 — — CN disclosed
WO-2021130492-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMMATORY PROPERTIES SITRYX THERAPEUTICS LIMITED (GB) 2021-07-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230219907-A1 CARBOXY DERIVATIVES WITH ANTIINFLAMATORY PROPERTIES CPA2, RO60, C5AR1 TP53 2221/4885MITF 4809/4885NCOA3 1375/4885
US-12617762-B2 Carboxy derivatives with antiinflamatory properties CCR1, CBR1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 TP53 2617/4885MITF 4718/4885NCOA3 779/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback