Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1402921 | 0.74 | HDAC3 (0.45) | POLB | |
| SCHEMBL1403328 | 0.73 | HDAC3 (0.43) | POLB | |
| SCHEMBL1403521 | 0.72 | HDAC4 (0.56) | — | |
| SCHEMBL1403219 | 0.72 | CTSL (0.44) | MAPT | |
| SCHEMBL7410334 | 0.69 | ALDH1A1 (0.37) | KMT2AMEN1MAPT | |
| SCHEMBL2466830 | 0.67 | EPHX1 (0.55) | POLBKMT2AMEN1 | |
| SCHEMBL8211806 | 0.65 | PYGL (0.36) | POLBKMT2AMEN1MAPT | |
| SCHEMBL8209525 | 0.65 | KMT2A (0.37) | POLBKMT2AMEN1MAPT | |
| SCHEMBL3563505 | 0.65 | MIF (0.43) | — | |
| SCHEMBL3607845 | 0.65 | SLC1A3 (0.49) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230241076-A1 | HISTONE-ACETYLATION-MODULATING AGENTS FOR THE TREATMENT AND PREVENTION OF ORGAN INJURY | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2023-08-03 | — | — | US | disclosed |
| EP-4171219-A2 | HISTONE-ACETYLATION-MODULATING AGENTS FOR THE TREATMENT AND PREVENTION OF ORGAN INJURY | The Regents Of The University Of Michigan (US) | 2023-05-03 | — | — | EP | disclosed |
| CN-115867133-A | Histone acetylation modulators for the treatment and prevention of organ injury | 密歇根大学董事会 | 2023-03-28 | — | — | CN | disclosed |
| WO-2022006133-A2 | HISTONE-ACETYLATION-MODULATING AGENTS FOR THE TREATMENT AND PREVENTION OF ORGAN INJURY | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-01-06 | — | — | WO | disclosed |
| WO-2021041836-A1 | PRESERVATION OF ORGANS FOR TRANSPLANT AND NON-TRANSPLANT SURGERIES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-03-04 | — | — | WO | disclosed |
| US-9370506-B2 | Modulators of aldehyde dehydrogenase and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150182506-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2015-07-02 | — | — | US | disclosed |
| US-20140343045-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-11-20 | — | — | US | disclosed |
| US-8772295-B2 | Modulators of aldehyde dehydrogenase and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-07-08 | — | — | US | disclosed |
| US-20130267501-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-10-10 | — | — | US | disclosed |
| US-8389522-B2 | Modulators of aldehyde dehydrogenase and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-03-05 | — | — | US | disclosed |
| EP-2349279-A1 | MODULATORS OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF | The Board of Trustees of The Leland Stanford Junior University (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010062308-A1 | MODULATORS OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2010-06-03 | — | — | WO | disclosed |
| US-20100113423-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230241076-A1 | HISTONE-ACETYLATION-MODULATING AGENTS FOR THE TREATMENT AND PREVENTION OF ORGAN INJURY | HDAC2, HDAC1, CREBBP | POLB 1990/4885OPRK1 1375/4885KMT2A 408/4885 |
| US-20140343045-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | ALDH2, ALDH3A1, ALDH1A1 | POLB 676/4885OPRK1 1523/4885KMT2A 2109/4885 |
| US-20150182506-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | ALDH2, ALDH3A1, ALDH1A1 | POLB 676/4885OPRK1 1523/4885KMT2A 2109/4885 |
| US-20130267501-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | ALDH2, ALDH3A1, ALDH1A1 | POLB 676/4885OPRK1 1523/4885KMT2A 2109/4885 |
| US-20100113423-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | ALDH2, ALDH3A1, ALDH1A1 | POLB 676/4885OPRK1 1523/4885KMT2A 2109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.