Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HPD | P32754 | 1/20 | 0.32 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30183682 | 0.83 | SIRT6 (0.43) | LMNAMAPTMPITDP1GAA | |
| SCHEMBL23591246 | 0.81 | MAPT (0.32) | LMNAMAPTHPGDALDH1A1MAPK1 | |
| SCHEMBL23577725 | 0.70 | SIRT6 (0.40) | LMNAMAPTTDP1GAAHPGD | |
| SCHEMBL23591009 | 0.70 | ALDH1A1 (0.40) | LMNAMAPTMPITDP1GAA | |
| SCHEMBL23578343 | 0.69 | SIRT6 (0.44) | LMNAMAPTCYP3A4MPITDP1 | |
| SCHEMBL28965721 | 0.69 | ALDH1A1 (0.40) | LMNAMAPTMPITDP1GAA | |
| SCHEMBL31419414 | 0.68 | CASP1 (0.50) | LMNATDP1GAAALDH1A1KMT2A | |
| SCHEMBL3592128 | 0.68 | CASP1 (0.50) | LMNATDP1GAAALDH1A1KMT2A | |
| SCHEMBL28816712 | 0.68 | PDK1 (0.42) | LMNAHPDHPGDHTTNPSR1 | |
| SCHEMBL23591103 | 0.67 | KRAS (0.34) | MPITDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130731-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS | LUPIN LIMITED (IN) | 2021-07-01 | — | — | WO | disclosed |