Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23601273 | 0.90 | TDP1 (0.39) | AOC3DHODHMTNR1AMTNR1BCHEK1 | |
| SCHEMBL23601197 | 0.82 | MAPT (0.43) | MTNR1AMTNR1BALDH1A1HPGDKDM4E | |
| SCHEMBL23577153 | 0.81 | AOC3 (0.38) | AOC3DHODHPARP1BACE1MTNR1A | |
| SCHEMBL29909552 | 0.81 | AOC3 (0.38) | AOC3DHODHPARP1BACE1MTNR1A | |
| SCHEMBL23601707 | 0.76 | PDE5A (0.42) | DHODHKDR | |
| SCHEMBL23601857 | 0.75 | DHODH (0.35) | DHODHALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL23601250 | 0.73 | DHODH (0.33) | DHODHMAPT | |
| SCHEMBL23601374 | 0.73 | DHODH (0.37) | DHODHHPGDMAP4K4 | |
| SCHEMBL23600472 | 0.73 | KDM4E (0.34) | DHODHALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL23601587 | 0.73 | EGFR (0.34) | DHODHBACE1CHEK1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |