Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.34 |
| ▸ | KDR | P35968 | 4/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23601857 | 0.91 | DHODH (0.35) | DHODHNPC1RAB9AALDH1A1DYRK1A | |
| SCHEMBL23600472 | 0.87 | KDM4E (0.34) | DHODHALDH1A1MEN1KMT2A | |
| SCHEMBL23601785 | 0.84 | EGFR (0.34) | EGFRPDGFRBKDRPDGFRADHODH | |
| SCHEMBL23601250 | 0.81 | DHODH (0.33) | DHODHDYRK1A | |
| SCHEMBL29909055 | 0.81 | ALDH1A1 (0.36) | EGFRPDGFRBKDRNPC1RAB9A | |
| SCHEMBL23576801 | 0.81 | ALDH1A1 (0.36) | EGFRPDGFRBKDRNPC1RAB9A | |
| SCHEMBL23601391 | 0.79 | EGFR (0.46) | EGFRPDGFRBKDRPDGFRA | |
| SCHEMBL23601707 | 0.78 | PDE5A (0.42) | EGFRPDGFRBKDRDHODH | |
| SCHEMBL23601637 | 0.73 | DHODH (0.32) | DHODH | |
| SCHEMBL23601723 | 0.72 | PDE5A (0.36) | CHEK1ALDH1A1DYRK1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |