Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23601707 | 0.93 | PDE5A (0.42) | PDE5A | |
| SCHEMBL23601210 | 0.91 | PDE5A (0.36) | PDE5AHTR6MAPT | |
| SCHEMBL23601069 | 0.85 | PDE5A (0.37) | PDE5AMAPTCDK2GSK3BDYRK1A | |
| SCHEMBL23601804 | 0.84 | CHEK1 (0.38) | PDE5AMEN1KMT2AMAPTCHEK1 | |
| SCHEMBL23601722 | 0.83 | PDE5A (0.36) | PDE5A | |
| SCHEMBL23601557 | 0.81 | LMNA (0.40) | ALDH1A1 | |
| SCHEMBL23601391 | 0.81 | EGFR (0.46) | — | |
| SCHEMBL23601519 | 0.78 | ABCG2 (0.46) | MEN1KMT2AMAPTGSK3BALDH1A1 | |
| SCHEMBL23601308 | 0.77 | CSNK2A1 (0.39) | MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL23601197 | 0.77 | MAPT (0.43) | MEN1KMT2AMAPTIMPDH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021130638-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES, INC. (JP) | 2021-07-01 | — | — | WO | disclosed |