Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | NMT2 | O60551 | 1/20 | 0.35 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22266609 | 0.85 | FOLH1 (0.36) | FOLH1CTSKSIRT6SIRT1NMT2 | |
| SCHEMBL13049083 | 0.83 | FOLH1 (0.57) | FOLH1SLC6A5CPB2MMP9 | |
| SCHEMBL29187387 | 0.83 | FOLH1 (0.57) | FOLH1SLC6A5CPB2MMP9 | |
| SCHEMBL24824249 | 0.83 | HPGDS (0.42) | FOLH1CTSKGRIA1SIRT6SIRT1 | |
| SCHEMBL19647271 | 0.83 | SIRT6 (0.42) | FOLH1CTSKGRIA1SIRT6SIRT1 | |
| SCHEMBL14961163 | 0.81 | SIRT6 (0.43) | FOLH1SIRT6SIRT1NMT2NMT1 | |
| SCHEMBL21566743 | 0.81 | SIRT6 (0.54) | FOLH1SIRT6SIRT1 | |
| SCHEMBL16557402 | 0.81 | SIRT6 (0.54) | FOLH1SIRT6SIRT1 | |
| SCHEMBL14961162 | 0.81 | SIRT6 (0.43) | FOLH1SIRT6SIRT1NMT2NMT1 | |
| SCHEMBL23053207 | 0.80 | NMT1 (0.43) | FOLH1SIRT6SIRT1NMT2NMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3327027-B9 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2021-07-07 | — | — | EP | disclosed |