Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 4/20 | 0.40 |
| ▸ | MMP3 | P08254 | 4/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 3/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24824249 | 0.90 | HPGDS (0.42) | SIRT6SIRT1FOLH1CTSKGRIA1 | |
| SCHEMBL13049083 | 0.86 | FOLH1 (0.57) | FOLH1MMP9CPB2 | |
| SCHEMBL29187387 | 0.86 | FOLH1 (0.57) | FOLH1MMP9CPB2 | |
| SCHEMBL23615418 | 0.83 | FOLH1 (0.40) | SIRT6SIRT1FOLH1MMP1MMP3 | |
| Hydrochloric Acid SCHEMBL28675933 | 0.82 | CTSK (0.43) | FOLH1CTSKCPB2 | |
| Hydrochloric Acid SCHEMBL28675934 | 0.82 | CTSK (0.43) | FOLH1CTSKCPB2 | |
| SCHEMBL20435077 | 0.82 | SIRT6 (0.58) | SIRT6SIRT1FOLH1 | |
| SCHEMBL12749404 | 0.82 | SIRT6 (0.58) | SIRT6SIRT1FOLH1 | |
| SCHEMBL20435058 | 0.82 | SIRT6 (0.58) | SIRT6SIRT1FOLH1 | |
| SCHEMBL16589724 | 0.81 | SIRT6 (0.55) | SIRT6SIRT1MMP1MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2017-11-29 | — | — | EP | disclosed |