Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.31 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29596517 | 0.73 | HDAC1 (0.31) | — | |
| SCHEMBL22911964 | 0.73 | HDAC1 (0.31) | — | |
| SCHEMBL29317272 | 0.73 | NOS3 (0.33) | NOS3NOS2NOS1 | |
| SCHEMBL29350657 | 0.73 | ADRA2A (0.37) | — | |
| SCHEMBL1137069 | 0.73 | ADRA2A (0.37) | — | |
| SCHEMBL15903111 | 0.72 | SIRT6 (0.38) | — | |
| SCHEMBL20469399 | 0.72 | — | — | |
| SCHEMBL20929102 | 0.71 | GRM5 (0.30) | — | |
| SCHEMBL16887487 | 0.71 | TLR7 (0.41) | NOS3NOS2NOS1 | |
| SCHEMBL31398410 | 0.71 | KCNJ1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021136464-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2021-07-08 | — | — | WO | disclosed |
| CN-104884059-A | Mixed lineage kinase inhibitors for hiv/aids therapies | UNIV ROCHESTER | 2015-09-02 | — | — | CN | disclosed |
| CN-104592231-A | Novel Tricyclic Compounds | ABBVIE INC | 2015-05-06 | — | — | CN | disclosed |
| CN-104370909-A | Novel tricyclic compounds | ABBOTT LAB | 2015-02-25 | — | — | CN | disclosed |
| CN-102264743-B | MLK inhibitors and methods of use | UNIV ROCHESTER | 2015-02-11 | — | — | CN | disclosed |
| CN-102711476-B | Novel tricyclic compounds | ABBVIE LAB | 2014-12-03 | — | — | CN | disclosed |
| CN-103987709-A | Process for preparing compounds useful as inhibitors of ATR kinase | VERTEX PHARMA | 2014-08-13 | — | — | CN | disclosed |
| CN-103958507-A | Compounds useful as inhibitors of ATR kinase | VERTEX PHARMA | 2014-07-30 | — | — | CN | disclosed |
| CN-103228651-A | Compounds useful as inhibitors of atr kinase | VERTEX PHARMA | 2013-07-31 | — | — | CN | disclosed |