Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 5/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 5/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 5/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29944222 | 1.00 | KDM4E (0.36) | KDM4EGAAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL23630384 | 0.84 | PRMT1 (0.39) | KDM4EGAAALDH1A1HDAC3SMARCA2 | |
| SCHEMBL29944247 | 0.84 | PRMT1 (0.39) | KDM4EGAAALDH1A1HDAC3SMARCA2 | |
| SCHEMBL29944092 | 0.73 | ALDH1A1 (0.55) | KDM4EGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL23630485 | 0.73 | ALDH1A1 (0.55) | KDM4EGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL23037194 | 0.73 | SLC6A9 (0.39) | SMARCA2SMARCA4PBRM1NR1I2 | |
| SCHEMBL31179812 | 0.73 | SLC6A9 (0.39) | SMARCA2SMARCA4PBRM1NR1I2 | |
| SCHEMBL25043720 | 0.72 | NCF1 (0.50) | KDM4EALDH1A1SMN1; SMN2SMARCA2SMARCA4 | |
| SCHEMBL23630324 | 0.72 | SMO (0.45) | KDM4EGAAALDH1A1POLBNPC1 | |
| SCHEMBL23630521 | 0.72 | PRKCQ (0.40) | KDM4EGAAALDH1A1SMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230091042-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2023-03-23 | — | — | US | disclosed |
| EP-4087658-A1 | SMARCA2-VHL DEGRADERS | Amgen Inc. (US) | 2022-11-16 | — | — | EP | disclosed |
| WO-2021142247-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2021-07-15 | — | — | WO | disclosed |
| WO-2021142247-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2021-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230091042-A1 | SMARCA2-VHL DEGRADERS | VHL, SMARCC2, SMARCC1 | KDM4E 178/4885GAA 633/4885ALDH1A1 1744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.