SCHEMBL23631817

SCHEMBL23631817

COc1ccc(C#N)cc1-c1cc(NS(=O)(=O)c2c(OC)cccc2OC)no1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NR3C2 P08235 1/20 0.49
SCN9A Q15858 6/20 0.43
ALPL P05186 2/20 0.43
TP53 P04637 2/20 0.43
ACLY P53396 2/20 0.41
KAT6A Q92794 5/20 0.39
KAT7 O95251 4/20 0.39
KAT6B Q8WYB5 3/20 0.39
KAT5 Q92993 1/20 0.38
KAT8 Q9H7Z6 1/20 0.38
TRIM24 O15164 1/20 0.38
MAPT P10636 1/20 0.38
SLC22A12 Q96S37 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23635883 0.84 KDM4E (0.50) TP53KAT6AKAT7KAT6BKAT5
SCHEMBL23631827 0.84 ALDH1A1 (0.51) TP53MAPT
SCHEMBL23635956 0.84 MAPT (0.47) NR3C2SCN9ATP53KAT6AKAT7
SCHEMBL23631813 0.84 KMT2A (0.47) ALPLKAT6AKAT7KAT6BKAT5
SCHEMBL23292514 0.82 TSHR (0.46) SCN9AALPLACLYKAT6AKAT7
SCHEMBL23631795 0.81 KAT7 (0.43) TP53KAT6AKAT7KAT6BKAT5
SCHEMBL27097779 0.81 MAPT (0.48) SCN9AALPLMAPT
SCHEMBL23631841 0.81 RAB9A (0.46) ALPLTP53ACLYKAT6AMAPT
SCHEMBL23635893 0.80 SCN9A (0.42) SCN9AKAT6AKAT7KAT6BKAT5
SCHEMBL23635968 0.77 STAT3 (0.50) KAT6AKAT7KAT6BKAT5KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240277683-A1 COMPOUNDS CTXT PTY LTD (AU) 2024-08-22 US disclosed
US-11911372-B2 Compounds CTXT PTY LTD (AU) 2024-02-27 US disclosed
US-11911372-B2 Compounds CTXT PTY LTD (AU) 2024-02-27 US disclosed
US-11911372-B2 Compounds CTXT PTY LTD (AU) 2024-02-27 US disclosed
US-20210213004-A1 Compounds CTXT PTY LTD (AU) 2021-07-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240277683-A1 COMPOUNDS SLC10A1, ABCB11, REN NR3C2 69/4885SCN9A 172/4885ALPL 953/4885
US-20210213004-A1 Compounds SLC10A1, ABCB11, REN NR3C2 72/4885SCN9A 163/4885ALPL 1275/4885
US-11911372-B2 Compounds SLC10A1, ABCB11, REN NR3C2 72/4885SCN9A 163/4885ALPL 1275/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.