SCHEMBL23635893

SCHEMBL23635893

COc1ccc(C2CC2)cc1-c1cc(NS(=O)(=O)c2c(OC)cccc2OC)no1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 5/20 0.42
KAT6A Q92794 10/20 0.42
KAT7 O95251 9/20 0.42
KAT6B Q8WYB5 8/20 0.42
KAT5 Q92993 5/20 0.42
KAT8 Q9H7Z6 5/20 0.42
HTT P42858 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
SCD5 Q86SK9 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
BRD4 O60885 1/20 0.37
BRD2 P25440 1/20 0.37
BRD3 Q15059 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23635883 0.84 KDM4E (0.50) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL23631827 0.83 ALDH1A1 (0.51) NPC1RAB9AMEN1KMT2A
SCHEMBL23635956 0.83 MAPT (0.47) SCN9AKAT6AKAT7NPC1RAB9A
SCHEMBL23631813 0.83 KMT2A (0.47) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL23292514 0.81 TSHR (0.46) SCN9AKAT6AKAT7KAT6BKAT5
SCHEMBL23635850 0.81 NR3C1 (0.41) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL23631817 0.80 NR3C2 (0.49) SCN9AKAT6AKAT7KAT6BKAT5
SCHEMBL23631795 0.80 KAT7 (0.43) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL23631841 0.80 RAB9A (0.46) KAT6ANPC1RAB9AMEN1KMT2A
SCHEMBL27097779 0.80 MAPT (0.48) SCN9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11911372-B2 Compounds CTXT PTY LTD (AU) 2024-02-27 US disclosed
US-11911372-B2 Compounds CTXT PTY LTD (AU) 2024-02-27 US disclosed
US-20210213004-A1 Compounds CTXT PTY LTD (AU) 2021-07-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210213004-A1 Compounds SLC10A1, ABCB11, REN SCN9A 163/4885KAT6A 951/4885KAT7 490/4885
US-11911372-B2 Compounds SLC10A1, ABCB11, REN SCN9A 163/4885KAT6A 951/4885KAT7 490/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.