Sugi Predict

Sugi Predict / Compounds / SCHEMBL23633381

SCHEMBL23633381

SCHEMBL23633381

CC(C)n1ncc2c(N(C(=O)c3ccc(F)cc3)C(=O)c3ccc(F)cc3)cc(-c3cccs3)nc21

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ RXFP1 Q9HBX9 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ MAPT P10636 2/20 0.39
▸ TP53 P04637 1/20 0.39
▸ GGPS1 O95749 1/20 0.38
▸ KDM4E B2RXH2 6/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ RECQL P46063 1/20 0.37
▸ HPGD P15428 1/20 0.36
▸ CAMK2D Q13557 2/20 0.36
▸ ADORA2A P29274 3/20 0.35
▸ ADORA3 P0DMS8 2/20 0.35
▸ KMT2A Q03164 3/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ POLB P06746 1/20 0.35
▸ ADORA1 P30542 2/20 0.35
▸ MET P08581 1/20 0.34
▸ GRM1 Q13255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23633382 0.81 KDM4E (0.45) RXFP1L3MBTL1MAPTTP53GGPS1
SCHEMBL23633377 0.78 TP53 (0.50) RXFP1L3MBTL1MAPTTP53GGPS1
SCHEMBL20870047 0.76 PDE11A (0.39) RXFP1MAPTKDM4EALDH1A1HPGD
SCHEMBL23633380 0.74 PPARG (0.42) MAPTTP53KDM4EALDH1A1HPGD
SCHEMBL16783143 0.73 RXFP1 (0.47) RXFP1L3MBTL1MAPTKDM4EALDH1A1
SCHEMBL16783120 0.73 RXFP1 (0.54) RXFP1L3MBTL1MAPTTP53KDM4E
SCHEMBL18688479 0.73 CSNK2A1 (0.43) L3MBTL1MAPTKDM4EALDH1A1HPGD
SCHEMBL16783148 0.73 RXFP1 (0.46) RXFP1L3MBTL1MAPTTP53KDM4E
SCHEMBL23633372 0.72 ALDH1A1 (0.45) L3MBTL1MAPTKDM4EALDH1A1HPGD
SCHEMBL16783112 0.72 RXFP1 (0.48) RXFP1L3MBTL1MAPTTP53KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11787799-B2 Potent antiviral pyrazolopyridine compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-10-17 — — US disclosed
US-11787799-B2 Potent antiviral pyrazolopyridine compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-10-17 — — US disclosed
US-20220119384-A1 POTENT ANTIVIRAL PYRAZOLOPYRIDINE COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-04-21 — — US disclosed
US-11059817-B2 Potent antiviral pyrazolopyridine compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-07-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787799-B2 Potent antiviral pyrazolopyridine compounds MAVS, VRK1, VRK2 RXFP1 1136/4885L3MBTL1 3199/4885MAPT 4023/4885
US-20220119384-A1 POTENT ANTIVIRAL PYRAZOLOPYRIDINE COMPOUNDS MAVS, VRK1, VRK2 RXFP1 1136/4885L3MBTL1 3199/4885MAPT 4023/4885
US-11059817-B2 Potent antiviral pyrazolopyridine compounds MAVS, VRK1, VRK2 RXFP1 1136/4885L3MBTL1 3199/4885MAPT 4023/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.