Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.49 |
| ▸ | MAT2A | P31153 | 3/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16783111 | 0.89 | L3MBTL1 (0.49) | TP53PSMD14L3MBTL1MAT2AOPRM1 | |
| SCHEMBL23633374 | 0.88 | OPRM1 (0.48) | TP53PSMD14L3MBTL1MAT2AOPRM1 | |
| SCHEMBL16783143 | 0.88 | RXFP1 (0.47) | PSMD14L3MBTL1MAT2AOPRM1OPRD1 | |
| SCHEMBL16783120 | 0.88 | RXFP1 (0.54) | TP53PSMD14L3MBTL1MAT2AOPRM1 | |
| SCHEMBL16783112 | 0.87 | RXFP1 (0.48) | TP53PSMD14L3MBTL1MAT2AOPRM1 | |
| SCHEMBL16783148 | 0.87 | RXFP1 (0.46) | TP53PSMD14L3MBTL1MAT2AOPRM1 | |
| SCHEMBL16783145 | 0.86 | OPRM1 (0.51) | PSMD14L3MBTL1MAT2AOPRM1OPRD1 | |
| SCHEMBL23633375 | 0.85 | MAT2A (0.49) | TP53PSMD14L3MBTL1MAT2AOPRM1 | |
| SCHEMBL20869961 | 0.84 | TP53 (0.51) | TP53KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL16783126 | 0.84 | RXFP1 (0.55) | TP53PSMD14L3MBTL1MAT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180498-B2 | Substituted pyrrolo[2,3-b]pyridines, pyrazolo[3,4-d]pyrimidines and [1,2,3]triazolo[4,5-b]pyridines as potent antivirals | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-23 | — | — | US | disclosed |
| US-11059817-B2 | Potent antiviral pyrazolopyridine compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11180498-B2 | Substituted pyrrolo[2,3-b]pyridines, pyrazolo[3,4-d]pyrimidines and [1,2,3]triazolo[4,5-b]pyridines as potent antivirals | PNPO, TYMS, TYMP | TP53 2623/4885PSMD14 4306/4885L3MBTL1 2588/4885 |
| US-11059817-B2 | Potent antiviral pyrazolopyridine compounds | MAVS, VRK1, VRK2 | TP53 3148/4885PSMD14 3464/4885L3MBTL1 3199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.