Sugi Predict

Sugi Predict / Compounds / SCHEMBL23633372

SCHEMBL23633372

SCHEMBL23633372

CC(C)n1ncc2c(C(C)(C)C)cc(-c3cccs3)nc21

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 11/20 0.45
▸ GAA P10253 6/20 0.45
▸ KDM4E B2RXH2 12/20 0.40
▸ HPGD P15428 6/20 0.40
▸ CSNK2A1 P68400 2/20 0.40
▸ LMNA P02545 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.38
▸ MAPT P10636 3/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ CYP2D6 P10635 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37
▸ GLA P06280 1/20 0.37
▸ TDP1 Q9NUW8 2/20 0.37
▸ L3MBTL1 Q9Y468 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24333876 0.85 ALDH1A1 (0.41) ALDH1A1GAAKDM4EHPGDCSNK2A1
SCHEMBL18688479 0.84 CSNK2A1 (0.43) ALDH1A1GAAKDM4EHPGDCSNK2A1
SCHEMBL23633375 0.74 MAT2A (0.49) ALDH1A1GAAKDM4EHPGDHSD17B10
SCHEMBL23633374 0.73 OPRM1 (0.48) ALDH1A1GAAKDM4EHPGDLMNA
SCHEMBL16783126 0.73 RXFP1 (0.55) ALDH1A1GAAKDM4EHPGDLMNA
SCHEMBL18688540 0.73 KDM4E (0.43) ALDH1A1GAAKDM4EHPGDHSD17B10
SCHEMBL820797 0.72 MEN1 (0.55) ALDH1A1GAAKDM4EHPGDLMNA
SCHEMBL23633377 0.72 TP53 (0.50) ALDH1A1GAAKDM4EHPGDLMNA
SCHEMBL23633371 0.72 RXFP1 (0.41) ALDH1A1GAAKDM4EHPGDCSNK2A1
SCHEMBL23633381 0.72 RXFP1 (0.39) ALDH1A1KDM4EHPGDMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11787799-B2 Potent antiviral pyrazolopyridine compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-10-17 — — US disclosed
US-11787799-B2 Potent antiviral pyrazolopyridine compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-10-17 — — US disclosed
US-20220119384-A1 POTENT ANTIVIRAL PYRAZOLOPYRIDINE COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-04-21 — — US disclosed
US-11059817-B2 Potent antiviral pyrazolopyridine compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-07-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787799-B2 Potent antiviral pyrazolopyridine compounds MAVS, VRK1, VRK2 ALDH1A1 2083/4885GAA 1375/4885KDM4E 3301/4885
US-20220119384-A1 POTENT ANTIVIRAL PYRAZOLOPYRIDINE COMPOUNDS MAVS, VRK1, VRK2 ALDH1A1 2083/4885GAA 1375/4885KDM4E 3301/4885
US-11059817-B2 Potent antiviral pyrazolopyridine compounds MAVS, VRK1, VRK2 ALDH1A1 2083/4885GAA 1375/4885KDM4E 3301/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.