Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLTP | P55058 | 7/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491471 | 0.90 | RORC (0.45) | PLTPRORCDGAT1ADORA2AADORA1 | |
| SCHEMBL2313071 | 0.85 | PLTP (0.50) | PLTPRORCDGAT1ADORA2AADORA1 | |
| SCHEMBL2318436 | 0.84 | PLTP (0.50) | PLTPRORCDGAT1ADORA2AADORA1 | |
| SCHEMBL2316639 | 0.83 | DGAT1 (0.46) | PLTPRORCDGAT1ADORA2AADORA1 | |
| SCHEMBL2316402 | 0.83 | PLTP (0.51) | PLTPRORCDGAT1ADORA2AADORA1 | |
| SCHEMBL2314202 | 0.82 | PLTP (0.47) | PLTPRORCDGAT1ADORA2AADORA1 | |
| SCHEMBL2315059 | 0.81 | PLTP (0.47) | PLTPRORCDGAT1ADORA2AADORA1 | |
| SCHEMBL2313698 | 0.81 | PLTP (0.49) | PLTPRORCDGAT1ADORA2AADORA1 | |
| SCHEMBL2319840 | 0.80 | PLTP (0.48) | PLTPRORCDGAT1ADORA2AADORA1 | |
| SCHEMBL2316924 | 0.78 | LMNA (0.52) | PLTPRORCDGAT1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349484-A2 | HETEROARYL DERIVATIVES AS DGAT1 INHIBITORS | Novartis AG (CH) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010007046-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-01-21 | — | — | WO | disclosed |