SCHEMBL23635949

SCHEMBL23635949

COc1ccc(-c2ncco2)cc1-c1cc(NS(=O)(=O)c2c(OC)cccc2OC)no1

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ACLY P53396 1/20 0.42
KAT6A Q92794 9/20 0.40
KAT7 O95251 8/20 0.40
KAT6B Q8WYB5 5/20 0.40
EDNRB P24530 6/20 0.39
EDNRA P25101 6/20 0.39
KAT5 Q92993 1/20 0.39
KAT8 Q9H7Z6 1/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
SCN9A Q15858 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23292514 0.84 TSHR (0.46) ACLYKAT6AKAT7KAT6BKAT5
SCHEMBL23292635 0.81 KAT6A (0.45) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL23635954 0.81 BRD4 (0.46) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL23635883 0.80 KDM4E (0.50) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL23631827 0.80 ALDH1A1 (0.51) MEN1KMT2A
SCHEMBL23635981 0.80 MEN1 (0.39) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL23635956 0.79 MAPT (0.47) KAT6AKAT7MEN1KMT2ASCN9A
SCHEMBL23631813 0.79 KMT2A (0.47) KAT6AKAT7KAT6BEDNRBEDNRA
SCHEMBL23631817 0.79 NR3C2 (0.49) ACLYKAT6AKAT7KAT6BKAT5
SCHEMBL23292532 0.79 APLNR (0.40) KAT6AKAT7KAT6BKAT5KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11911372-B2 Compounds CTXT PTY LTD (AU) 2024-02-27 US disclosed
US-11911372-B2 Compounds CTXT PTY LTD (AU) 2024-02-27 US disclosed
US-20210213004-A1 Compounds CTXT PTY LTD (AU) 2021-07-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210213004-A1 Compounds SLC10A1, ABCB11, REN ACLY 2666/4885KAT6A 951/4885KAT7 490/4885
US-11911372-B2 Compounds SLC10A1, ABCB11, REN ACLY 2666/4885KAT6A 951/4885KAT7 490/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.