Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 2/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2363650 | 0.85 | VCP (0.46) | TNKSTNKS2LMNAVCPKDM4E | |
| SCHEMBL18568684 | 0.74 | POLB (0.59) | TNKSTNKS2LMNAKDM4EMEN1 | |
| SCHEMBL2355035 | 0.69 | VCP (0.44) | LMNAVCPMEN1HPGDKMT2A | |
| SCHEMBL2362584 | 0.67 | POLB (0.61) | LMNAKDM4EMEN1POLBHPGD | |
| SCHEMBL2357150 | 0.64 | MAPT (0.47) | TNKSTNKS2LMNAVCPKDM4E | |
| SCHEMBL2355147 | 0.63 | LMNA (0.44) | TNKSTNKS2LMNAVCPKDM4E | |
| SCHEMBL12024152 | 0.61 | HTT (0.58) | LMNAMEN1HPGDKMT2ATDP1 | |
| SCHEMBL24666254 | 0.59 | ABL1 (0.58) | — | |
| SCHEMBL19322789 | 0.59 | RORC (0.56) | TNKSTNKS2KDM4EHPGDTP53 | |
| SCHEMBL4023526 | 0.59 | CNR1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3135672-B9 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-3135672-B1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC (US) | 2020-02-19 | — | — | EP | disclosed |
| EP-3135672-B1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC (US) | 2020-02-19 | — | — | EP | disclosed |
| EP-3135672-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM Discovery, Inc. (US) | 2017-03-01 | — | — | EP | disclosed |
| EP-3135672-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM Discovery, Inc. (US) | 2017-03-01 | — | — | EP | disclosed |
| EP-2356109-B1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC (US) | 2016-12-07 | — | — | EP | disclosed |
| US-8729081-B2 | Compositions and methods for treating alcohol use disorders, pain and other diseases | VM DISCOVERY INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-8729081-B2 | Compositions and methods for treating alcohol use disorders, pain and other diseases | VM DISCOVERY INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2011-12-08 | — | — | US | disclosed |
| EP-2356109-A2 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM Discovery, Inc. (US) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010042925-A2 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | VM DISCOVERY INC. (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301149-A1 | COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES | PRKCH, PRKCG, PRKCQ | PRKD1 123/4885TNKS 2083/4885TNKS2 2126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.