Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGFR | P43088 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28177161 | 0.86 | TBXA2R (0.54) | ALDH1A1KDM4ELMNATSHRCAPN1 | |
| SCHEMBL3459871 | 0.76 | MAPK8 (0.46) | ALDH1A1KDM4ELMNATSHRCA1 | |
| SCHEMBL3461063 | 0.76 | TBXA2R (0.55) | ALDH1A1KDM4ELMNATSHRTBXA2R | |
| SCHEMBL3461101 | 0.76 | ADRA1D (0.49) | ALDH1A1KDM4ELMNAPARP1MEN1 | |
| SCHEMBL3462285 | 0.76 | MAPK8 (0.48) | KDM4EGAAPARP1 | |
| SCHEMBL1004028 | 0.76 | TSHR (0.58) | ALDH1A1KDM4ETSHRCAPN1CA1 | |
| SCHEMBL7134588 | 0.75 | TSHR (0.54) | ALDH1A1KDM4ETSHRGAACYP2C9 | |
| SCHEMBL5723934 | 0.74 | KEAP1 (0.56) | ALDH1A1KDM4ETSHRCA1CA2 | |
| SCHEMBL19439093 | 0.74 | TSHR (0.53) | ALDH1A1KDM4ELMNATSHRCAPN1 | |
| Hydrochloric Acid SCHEMBL15690391 | 0.74 | TSHR (0.56) | ALDH1A1KDM4ETSHRCAPN1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358697-A1 | Isoindoline compounds for use in the treatment of cancer | CELGENE CORPORATION (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010053732-A1 | ISOINDOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | CELGENE CORPORATION (US) | 2010-05-14 | — | — | WO | disclosed |