Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20561089 | 0.84 | KCNK3 (0.49) | ALDH1A1HCRTR1HCRTR2KCNK3KCNK9 | |
| SCHEMBL219458 | 0.82 | NAPRT (0.66) | NAPRTPRKCIKDM4EALDH1A1 | |
| SCHEMBL20561090 | 0.77 | SLC6A3 (0.47) | ALDH1A1SCN10AKCNK3KCNK9FFAR4 | |
| SCHEMBL2303054 | 0.76 | LTA4H (0.49) | NAPRTSCN10AATRTLR7SCN9A | |
| Hydrochloric Acid SCHEMBL28016225 | 0.76 | SLC6A3 (0.46) | ALDH1A1SCN10AKCNK3KCNK9FFAR4 | |
| SCHEMBL28016834 | 0.74 | HSD11B1 (0.52) | ALDH1A1CDK2KCNK3KCNK9FFAR4 | |
| Hydrochloric Acid SCHEMBL29857909 | 0.74 | LTA4H (0.47) | NAPRTSCN10AATRTLR7SCN9A | |
| SCHEMBL7542152 | 0.73 | CDK2 (0.44) | NAPRTDHODHSCN10AATRHCRTR1 | |
| SCHEMBL28016181 | 0.72 | MGLL (0.54) | KCNK3KCNK9FFAR4 | |
| SCHEMBL12951000 | 0.72 | NAPRT (0.56) | NAPRTPRKCIKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358202-A1 | BENZIMIDAZOLE AND AZA-BENZIMIDAZOLE CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2011-08-24 | — | — | EP | disclosed |