Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butane SCHEMBL2364965 | 0.96 | KDM4E (0.41) | KDM4EHTTPOLBALDH1A1NPC1 | |
| Butane SCHEMBL2364892 | 0.95 | KDM4E (0.40) | KDM4EHTTPOLBALDH1A1NPC1 | |
| Butane SCHEMBL3896794 | 0.94 | KDM4E (0.40) | KDM4EHTTPOLBALDH1A1NPC1 | |
| SCHEMBL14889404 | 0.93 | KDM4E (0.43) | KDM4EHTTPOLBALDH1A1NPC1 | |
| SCHEMBL12985731 | 0.92 | KDM4E (0.42) | KDM4EHTTPOLBALDH1A1NPC1 | |
| SCHEMBL17930846 | 0.92 | KDM4E (0.43) | KDM4EHTTPOLBALDH1A1NPC1 | |
| SCHEMBL14889460 | 0.91 | KDM4E (0.41) | KDM4EHTTPOLBALDH1A1NPC1 | |
| Butane SCHEMBL6362180 | 0.90 | NPC1 (0.39) | KDM4EHTTPOLBALDH1A1NPC1 | |
| Butane SCHEMBL3273854 | 0.90 | KDM4E (0.42) | KDM4EHTTPOLBALDH1A1NPC1 | |
| SCHEMBL17930826 | 0.89 | KDM4E (0.43) | KDM4EHTTPOLBALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761537-B1 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE-NAPTHALIMIDE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2011-08-03 | — | — | EP | disclosed |
| EP-1608663-B1 | PYRROLO (2,1-C)(1,4) BENZODIAZEPINES DIMERS AS ANTITUMOUR AGENTS AND PROCESS THEREOF | COUNCIL SCIENT IND RES (IN) | 2008-11-05 | — | — | EP | disclosed |
| EP-1761537-A1 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE-NAPTHALIMIDE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2007-03-14 | — | — | EP | disclosed |
| US-7015215-B2 | Pyrrolo[2,1-c][1,4] benzodiazepines compounds and process thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2006-03-21 | — | — | US | disclosed |
| WO-2006003670-A1 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE-NAPTHALIMIDE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2006-01-12 | — | — | WO | disclosed |
| US-20060003994-A1 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE-NAPTHALIMIDE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2006-01-05 | — | — | US | disclosed |
| US-6979684-B1 | Pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide conjugates linked through piperazine moiety and process for preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-12-27 | — | — | US | disclosed |
| US-20040192678-A1 | reacting N-(4-hydroxy-2-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal with dibromoalkanes, then condensing with piperazine, reducing and cyclization to form antitumor agents | WALLACK, MARC K., MR | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192678-A1 | reacting N-(4-hydroxy-2-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal with dibromoalkanes, then condensing with piperazine, reducing and cyclization to form antitumor agents | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, TOP2B, BRD4 | KDM4E 1065/4885HTT 692/4885POLB 534/4885 |
| US-20060003994-A1 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE-NAPTHALIMIDE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR PREPARATION THEREOF | GABRA5, GABRA1, GABRP | KDM4E 1524/4885HTT 2225/4885POLB 2417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.