Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butane SCHEMBL3896794 | 0.99 | KDM4E (0.40) | KDM4EHTTALDH1A1POLBMAPT | |
| Butane SCHEMBL2364965 | 0.97 | KDM4E (0.41) | KDM4EHTTALDH1A1POLBMAPT | |
| SCHEMBL12985731 | 0.97 | KDM4E (0.42) | KDM4EHTTALDH1A1POLBMAPT | |
| SCHEMBL14889460 | 0.96 | KDM4E (0.41) | KDM4EHTTALDH1A1POLBMAPT | |
| Butane SCHEMBL2364882 | 0.95 | KDM4E (0.41) | KDM4EHTTALDH1A1POLBHPGD | |
| SCHEMBL14889404 | 0.95 | KDM4E (0.43) | KDM4EHTTALDH1A1POLBMAPT | |
| SCHEMBL17930846 | 0.92 | KDM4E (0.43) | KDM4EHTTALDH1A1POLBMAPT | |
| Butane SCHEMBL3273854 | 0.90 | KDM4E (0.42) | KDM4EHTTALDH1A1POLBLMNA | |
| SCHEMBL17930826 | 0.89 | KDM4E (0.43) | KDM4EHTTALDH1A1POLBMAPT | |
| Butane SCHEMBL6362180 | 0.88 | NPC1 (0.39) | KDM4EHTTALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761537-B1 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE-NAPTHALIMIDE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2011-08-03 | — | — | EP | disclosed |
| EP-1608664-B1 | NON-CROSS-LINKING PYRROLO[2,1-C][1,4]BENZODIAZEPINES AS POTENTIAL ANTITUMOUR AGENTS AND PROCESS THEREOF | COUNCIL SCIENT IND RES (IN) | 2009-01-28 | — | — | EP | disclosed |
| EP-1761537-A1 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE-NAPTHALIMIDE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006003670-A1 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE-NAPTHALIMIDE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2006-01-12 | — | — | WO | disclosed |
| US-20060003994-A1 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE-NAPTHALIMIDE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2006-01-05 | — | — | US | disclosed |
| US-6979684-B1 | Pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide conjugates linked through piperazine moiety and process for preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-12-27 | — | — | US | disclosed |
| US-20050222133-A1 | PROCESS FOR PREPARING PYRROLO[2, 1-C] [1,4] BENZODIAZEPINE HYBRIDS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2005-10-06 | — | — | US | disclosed |
| US-6951853-B1 | Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine hybrids | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-10-04 | — | — | US | disclosed |
| WO-2005063759-A1 | PROCESS FOR PREPARING PYRROLO[2, 1-c] [1, 4] BENZODIAZEPINE HYBRIDS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-07-14 | — | — | WO | disclosed |
| US-6884799-B2 | Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines and process thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-04-26 | — | — | US | disclosed |
| US-20040192679-A1 | Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines and process thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192679-A1 | Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines and process thereof | GABRA1, GABRA4, GABRA5 | KDM4E 632/4885HTT 3770/4885ALDH1A1 362/4885 |
| US-20050222133-A1 | PROCESS FOR PREPARING PYRROLO[2, 1-C] [1,4] BENZODIAZEPINE HYBRIDS | PBRM1, GABRP, GABRA4 | KDM4E 740/4885HTT 3614/4885ALDH1A1 1305/4885 |
| US-20060003994-A1 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE-NAPTHALIMIDE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR PREPARATION THEREOF | GABRA5, GABRA1, GABRP | KDM4E 1524/4885HTT 2225/4885ALDH1A1 468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.