Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | TDO2 | P48775 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | SHBG | P04278 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL235761 | 0.83 | TTR (0.71) | TTRALDH1A1MAPK1HPGDMEN1 | |
| SCHEMBL236891 | 0.82 | TTR (0.70) | TTRALDH1A1MEN1KMT2AATM | |
| SCHEMBL232760 | 0.81 | TTR (0.67) | TTRALDH1A1MEN1KMT2AATM | |
| SCHEMBL2330812 | 0.80 | TTR (0.67) | TTRALDH1A1MAPK1HPGDMEN1 | |
| SCHEMBL332837 | 0.80 | TTR (0.66) | TTRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL5725941 | 0.79 | L3MBTL1 (0.68) | TTRALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1246697 | 0.78 | RAB9A (0.65) | TTRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL29535974 | 0.77 | MEN1 (0.70) | TTRALDH1A1MAPK1HPGDMEN1 | |
| SCHEMBL1039742 | 0.77 | SMN1; SMN2 (0.70) | TTRALDH1A1MAPK1HPGDMEN1 | |
| SCHEMBL31511913 | 0.77 | SMN1; SMN2 (0.70) | TTRALDH1A1MAPK1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230105307-A1 | Identification of Stabilizers of Multimeric Proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2023-04-06 | — | — | US | disclosed |
| US-11337935-B2 | Identification of stabilizers of multimeric proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2022-05-24 | — | — | US | disclosed |
| US-20200016098-A1 | Identification of Stabilizers of Multimeric Proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2020-01-16 | — | — | US | disclosed |
| US-10278929-B2 | Identification of stabilizers of multimeric proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-05-07 | — | — | US | disclosed |
| US-20190054040-A1 | Identification of Stabilizers of Multimeric Proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2019-02-21 | — | — | US | disclosed |
| US-10039726-B2 | Identification of stabilizers of multimeric proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2018-08-07 | — | — | US | disclosed |
| US-10039726-B2 | Identification of stabilizers of multimeric proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2018-08-07 | — | — | US | disclosed |
| EP-2346844-B1 | SUBSTITUTED BENZFUROCHROMENES FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL SCIENT IND RES (IN) | 2017-09-20 | — | — | EP | disclosed |
| US-20160374961-A1 | Identification of Stabilizers of Multimeric Proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2016-12-29 | — | — | US | disclosed |
| US-9308209-B2 | Identification of stabilizers of multimeric proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIO (US) | 2016-04-12 | — | — | US | disclosed |
| US-20150126532-A1 | Identification of Stabilizers of Multimeric Proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2015-05-07 | — | — | US | disclosed |
| US-20150126532-A1 | Identification of Stabilizers of Multimeric Proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2015-05-07 | — | — | US | disclosed |
| US-8877795-B2 | Identification of stabilizers of multimeric proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-11-04 | — | — | US | disclosed |
| US-8877795-B2 | Identification of stabilizers of multimeric proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-11-04 | — | — | US | disclosed |
| US-20130203777-A1 | Identification of Stabilizers of Multimeric Proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2013-08-08 | — | — | US | disclosed |
| US-20130203777-A1 | Identification of Stabilizers of Multimeric Proteins | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2013-08-08 | — | — | US | disclosed |
| US-20120003273-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) | 2012-01-05 | — | — | US | disclosed |
| WO-2011140333-A1 | IDENTIFICATION OF STABILIZERS OF MULTIMERIC PROTEINS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-11-10 | — | — | WO | disclosed |
| EP-2346844-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | Council Of Scientific & Industrial Research (IN) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010052734-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230105307-A1 | Identification of Stabilizers of Multimeric Proteins | TTR, HSPBP1, HSPH1 | TTR 1/4885ALDH1A1 3493/4885MAPK1 4185/4885 |
| US-20190054040-A1 | Identification of Stabilizers of Multimeric Proteins | TTR, HSPBP1, HSPH1 | TTR 1/4885ALDH1A1 3493/4885MAPK1 4185/4885 |
| US-10278929-B2 | Identification of stabilizers of multimeric proteins | TTR, HSPBP1, HSPH1 | TTR 1/4885ALDH1A1 3296/4885MAPK1 4347/4885 |
| US-11337935-B2 | Identification of stabilizers of multimeric proteins | TTR, HSPBP1, HSPH1 | TTR 1/4885ALDH1A1 3493/4885MAPK1 4185/4885 |
| US-20160374961-A1 | Identification of Stabilizers of Multimeric Proteins | TTR, ALB, HSPBP1 | TTR 1/4885ALDH1A1 3246/4885MAPK1 4777/4885 |
| US-10039726-B2 | Identification of stabilizers of multimeric proteins | TTR, ALB, HSPBP1 | TTR 1/4885ALDH1A1 3246/4885MAPK1 4777/4885 |
| US-20130203777-A1 | Identification of Stabilizers of Multimeric Proteins | TTR, HSPBP1, HSP90B1 | TTR 1/4885ALDH1A1 3222/4885MAPK1 4663/4885 |
| US-20150126532-A1 | Identification of Stabilizers of Multimeric Proteins | TTR, HSPBP1, HSPH1 | TTR 1/4885ALDH1A1 3493/4885MAPK1 4185/4885 |
| US-20200016098-A1 | Identification of Stabilizers of Multimeric Proteins | TTR, HSPBP1, HSPH1 | TTR 1/4885ALDH1A1 3493/4885MAPK1 4185/4885 |
| US-20120003273-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | AKR1C3, AKR1C4, SLC10A1 | TTR 2235/4885ALDH1A1 1999/4885MAPK1 3299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.