Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 1/20 | 0.51 |
| ▸ | GLS | O94925 | 6/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.48 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21981021 | 0.87 | AOC2 (0.51) | VNN1GLSMAPK14P2RY14NLRP3 | |
| SCHEMBL378549 | 0.84 | VNN1 (0.52) | VNN1GLSMAPK14CHRM2CHRM1 | |
| SCHEMBL11546048 | 0.83 | CHRM2 (0.51) | VNN1GLSMAPK14CHRM2CHRM1 | |
| SCHEMBL28475012 | 0.83 | VNN1 (0.56) | VNN1GLSMAPK14CHRM2CHRM1 | |
| SCHEMBL13329837 | 0.81 | NLRP3 (0.57) | VNN1NLRP3 | |
| SCHEMBL10154070 | 0.81 | POLB (0.60) | GLS | |
| SCHEMBL761677 | 0.81 | MAPK14 (0.54) | VNN1MAPK14CHRM2CHRM1CHRM3 | |
| SCHEMBL19914436 | 0.81 | VNN1 (0.48) | VNN1GLSMAPK14P2RY14FFAR2 | |
| SCHEMBL21484106 | 0.81 | CTSD (0.45) | VNN1GLSMAPK14P2RY14NLRP3 | |
| SCHEMBL21981003 | 0.80 | GLS (0.49) | VNN1GLSMAPK14P2RY14NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3954686-A1 | HETEROCYCLIC GLUTAMINASE INHIBITORS | Calithera Biosciences, Inc. (US) | 2022-02-16 | — | — | EP | disclosed |
| EP-2920168-B1 | HETEROCYCLIC GLUTAMINASE INHIBITORS | CALITHERA BIOSCIENCES INC (US) | 2021-07-21 | — | — | EP | disclosed |