Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.63 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.63 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.63 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.63 |
| ▸ | CCR2 | P41597 | 1/20 | 0.61 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KMO | O15229 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.53 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.53 |
| ▸ | LIPE | Q05469 | 2/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2365692 | 0.85 | L3MBTL1 (0.56) | PPARGIP6K1IP6K3IP6K2CCR2 | |
| SCHEMBL13366027 | 0.84 | NR1H2 (0.53) | PPARGIP6K1IP6K3IP6K2CCR2 | |
| SCHEMBL10985263 | 0.83 | RAB9A (0.70) | MRGPRX4LMNASMN1; SMN2KMONR4A2 | |
| SCHEMBL3506717 | 0.82 | KDM4E (0.60) | PPARGIP6K1IP6K3IP6K2CCR2 | |
| SCHEMBL9384901 | 0.81 | AKR1C3 (0.58) | PPARGCCR2MRGPRX4KMOAKR1C3 | |
| SCHEMBL11307569 | 0.80 | MAPK1 (0.69) | PPARGIP6K1IP6K3IP6K2CCR2 | |
| SCHEMBL1168418 | 0.79 | PPARG (0.62) | PPARGCCR2MRGPRX4KMOAKR1C3 | |
| SCHEMBL25989724 | 0.79 | IP6K1 (1.00) | PPARGIP6K1IP6K3IP6K2NPC1 | |
| SCHEMBL4910658 | 0.77 | CCR2 (1.00) | CCR2CYP2C9 | |
| SCHEMBL10818017 | 0.77 | TTR (0.61) | IP6K1IP6K3IP6K2MRGPRX4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927549-B2 | Adamantyl benzamide derivatives | HIGH POINT PHARMACEUTICALS, LLC (US) | 2015-01-06 | — | — | US | disclosed |
| US-20110224244-A1 | Adamantyl Benzamide Derivatives | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-09-15 | — | — | US | disclosed |
| EP-2362730-A1 | ADAMANTYL BENZAMIDE COMPOUNDS | High Point Pharmaceuticals, LLC (US) | 2011-09-07 | — | — | EP | disclosed |
| WO-2010059618-A1 | ADAMANTYL BENZAMIDE COMPOUNDS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224244-A1 | Adamantyl Benzamide Derivatives | HSD11B1, HSD17B11, HSD3B1 | PPARG 1286/4885IP6K1 3535/4885IP6K3 3760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.