Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1907864 | 0.88 | ADRA2A (0.37) | ADRA2AADRA2BADRA2C | |
| SCHEMBL2365641 | 0.84 | HTR2A (0.43) | — | |
| SCHEMBL6653629 | 0.74 | ADRA2A (0.35) | ADRA2AADRA2BADRA2C | |
| SCHEMBL6532681 | 0.74 | HTR2C (0.49) | — | |
| SCHEMBL1903335 | 0.72 | PTPN1 (0.35) | — | |
| SCHEMBL6631310 | 0.71 | FGFR4 (0.35) | — | |
| SCHEMBL2365900 | 0.71 | HTR2A (0.51) | — | |
| SCHEMBL6650634 | 0.70 | ALDH1A1 (0.39) | — | |
| SCHEMBL2365631 | 0.69 | DRD2 (0.40) | — | |
| SCHEMBL2477900 | 0.69 | HTR2A (0.58) | ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2363394-A1 | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its salts, solvates or hydrates and its use for the treatment of CNS disorders | Arena Pharmaceuticals, Inc. (US) | 2011-09-07 | — | — | EP | disclosed |