Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 4/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2365636 | 0.85 | HSD11B1 (0.48) | HSD11B1 | |
| SCHEMBL2365755 | 0.80 | PPARG (0.41) | P2RX7NPC1PKMMEN1KMT2A | |
| SCHEMBL2365727 | 0.80 | P2RX7 (0.37) | P2RX7NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL13366174 | 0.79 | BRAF (0.37) | BRAFKDRNPC1RAB9ATSHR | |
| SCHEMBL2365635 | 0.76 | IP6K1 (0.43) | P2RX7NPC1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL13366022 | 0.73 | BRAF (0.61) | BRAFKDRNPC1RAB9ATSHR | |
| SCHEMBL2365672 | 0.73 | HPGD (0.51) | BRAFKDRALDH1A1MEN1KMT2A | |
| SCHEMBL1675961 | 0.73 | FAAH (0.55) | P2RX7MEN1KMT2ATDP1HSD11B1 | |
| SCHEMBL2365633 | 0.69 | BRAF (0.47) | BRAFKDRNPC1RAB9AALDH1A1 | |
| SCHEMBL2365642 | 0.67 | FAAH (0.52) | TDP1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362730-A1 | ADAMANTYL BENZAMIDE COMPOUNDS | High Point Pharmaceuticals, LLC (US) | 2011-09-07 | — | — | EP | disclosed |
| WO-2010059618-A1 | ADAMANTYL BENZAMIDE COMPOUNDS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2010-05-27 | — | — | WO | disclosed |