Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | FAAH | O00519 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.53 |
| ▸ | LIPE | Q05469 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2365744 | 0.86 | LMNA (0.73) | MRGPRX4GAAMAPK1FAAHLMNA | |
| SCHEMBL6840278 | 0.84 | GAA (0.66) | MRGPRX4GAAMAPK1LMNAL3MBTL1 | |
| SCHEMBL30334648 | 0.84 | MAPK1 (0.55) | MRGPRX4GAAMAPK1FAAHLMNA | |
| SCHEMBL4327207 | 0.83 | LMNA (0.73) | MRGPRX4GAALMNAMAPTRAB9A | |
| SCHEMBL9170212 | 0.83 | MAPK1 (0.57) | MRGPRX4GAAMAPK1FAAHLMNA | |
| SCHEMBL10436236 | 0.83 | MAPK1 (0.63) | MRGPRX4GAAMAPK1FAAHLMNA | |
| SCHEMBL5926689 | 0.82 | LOXL2 (0.62) | MRGPRX4GAAMAPK1FAAHL3MBTL1 | |
| SCHEMBL24664169 | 0.81 | MAPK1 (0.57) | MRGPRX4GAAMAPK1FAAHLMNA | |
| SCHEMBL29123588 | 0.81 | MAPK1 (0.57) | MRGPRX4GAAMAPK1FAAHLMNA | |
| SCHEMBL5651111 | 0.81 | MAPK1 (0.67) | MRGPRX4GAAMAPK1FAAHLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927549-B2 | Adamantyl benzamide derivatives | HIGH POINT PHARMACEUTICALS, LLC (US) | 2015-01-06 | — | — | US | disclosed |
| US-20110224244-A1 | Adamantyl Benzamide Derivatives | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-09-15 | — | — | US | disclosed |
| EP-2362730-A1 | ADAMANTYL BENZAMIDE COMPOUNDS | High Point Pharmaceuticals, LLC (US) | 2011-09-07 | — | — | EP | disclosed |
| WO-2010059618-A1 | ADAMANTYL BENZAMIDE COMPOUNDS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2010-05-27 | — | — | WO | disclosed |
| US-4401460-A | Herbicidal phenoxypyridines | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-08-30 | — | — | US | disclosed |
| EP-0021613-B1 | PYRIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM, HERBICIDAL COMPOSITIONS CONTAINING THEM AND METHODS OF KILLING PLANTS THEREWITH | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-04-06 | — | — | EP | disclosed |
| US-4308053-A | PREEMERGENCE AND POSTEMERGENCE | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-12-29 | — | — | US | disclosed |
| EP-0021613-A1 | Pyridine derivatives, processes for preparing them, herbicidal compositions containing them and methods of killing plants therewith | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224244-A1 | Adamantyl Benzamide Derivatives | HSD11B1, HSD17B11, HSD3B1 | MRGPRX4 2741/4885GAA 411/4885MAPK1 2990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.