SCHEMBL23657266

SCHEMBL23657266

CCCCOc1ccc(SNCCc2c[nH]c3ccccc23)cc1

nearest known ligand 0.64

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 3/20 0.64
KCNH2 Q12809 1/20 0.64
MAPT P10636 2/20 0.52
HTR2A P28223 2/20 0.51
MTNR1A P48039 3/20 0.51
HTR1A P08908 3/20 0.51
HTR1D P28221 2/20 0.51
HTR1B P28222 2/20 0.51
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
HTT P42858 1/20 0.50
ACHE P22303 1/20 0.49
GAA P10253 1/20 0.49
MTNR1B P49286 1/20 0.47
G6PD P11413 1/20 0.46
MC5R P33032 1/20 0.46
MC3R P41968 1/20 0.46
MC1R Q01726 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23657358 0.94 KCNA5 (0.60) KCNA5KCNH2MAPTHTR2AMTNR1A
SCHEMBL23657162 0.92 KCNA5 (0.58) KCNA5KCNH2MAPTHTR2AMTNR1A
SCHEMBL23657408 0.85 HTR1A (0.53) KCNA5KCNH2MAPTHTR2AHTR1A
SCHEMBL23657293 0.85 HTR1A (0.55) MAPTHTR2AMTNR1AHTR1AHTR1D
SCHEMBL23657311 0.84 KCNA5 (0.48) KCNA5KCNH2MAPTHTR2AHTR1A
SCHEMBL23657351 0.84 HTR1A (0.53) KCNA5KCNH2MAPTHTR2AHTR1A
SCHEMBL23657278 0.84 KCNA5 (0.48) KCNA5KCNH2MAPTHTR2AMTNR1A
SCHEMBL23657359 0.84 SLC6A4 (0.58) KCNA5KCNH2MAPTHTR2AHTR1A
SCHEMBL23657177 0.84 SLC6A4 (0.55) KCNA5KCNH2MAPTHTR2AHTR1A
SCHEMBL23657372 0.81 HTR1A (0.54) KCNA5KCNH2HTR1AACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021145729-A1 NOVEL COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION (KR) 2021-07-22 WO disclosed