SCHEMBL2365753

SCHEMBL2365753

CCc1cnc(N2CCN(C(=O)c3cnc(F)c(C)c3)CC2)c(C)c1

nearest known ligand 0.43

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.43
KMT2A Q03164 4/20 0.43
P2RY12 Q9H244 14/20 0.41
SLC6A7 Q99884 1/20 0.40
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2366247 0.86 KDM4E (0.42) MEN1KMT2ASLC6A7MAPT
SCHEMBL27848382 0.81 SLC6A7 (0.42) MEN1KMT2AP2RY12SLC6A7MAPT
SCHEMBL2366420 0.81 KDM4E (0.38) SLC6A7
SCHEMBL2366289 0.81 SLC6A7 (0.44) MEN1KMT2AP2RY12SLC6A7MAPT
SCHEMBL14687427 0.81 ALDH1A1 (0.48) MEN1KMT2AP2RY12SLC6A7MAPT
SCHEMBL2365786 0.81 SLC6A7 (0.48) MEN1KMT2AP2RY12SLC6A7MAPT
SCHEMBL27848262 0.81 MEN1 (0.42) MEN1KMT2AP2RY12MAPT
SCHEMBL2365914 0.80 MEN1 (0.43) MEN1KMT2AP2RY12SLC6A7MAPT
SCHEMBL2366183 0.79 KMT2A (0.35) MEN1KMT2AP2RY12SLC6A7MAPT
SCHEMBL2366191 0.79 KMT2A (0.35) MEN1KMT2AP2RY12SLC6A7MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2364975-B1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORP (JP) 2013-06-12 EP disclosed
US-8354401-B2 Oxazolidinone amide aromatic compounds for supressing MMP-9 production MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-01-15 US disclosed
US-8354401-B2 Oxazolidinone amide aromatic compounds for supressing MMP-9 production MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-01-15 US disclosed
US-8354401-B2 Oxazolidinone amide aromatic compounds for supressing MMP-9 production MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-01-15 US disclosed
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-27 US disclosed
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-27 US disclosed
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-27 US disclosed
EP-2364975-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE Mitsubishi Tanabe Pharma Corporation (JP) 2011-09-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MMP9, MMP10, MMP2 MEN1 2896/4885KMT2A 800/4885P2RY12 4391/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.