SCHEMBL2365769

SCHEMBL2365769

Cc1cc(C)c(N2CCN(C(=O)c3ccc(N4CCOC4=O)cc3)CC2)nc1C

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43
C1S P09871 2/20 0.41
LMNA P02545 2/20 0.41
TSHR P16473 2/20 0.41
HTT P42858 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
CNR1 P21554 1/20 0.40
CNR2 P34972 1/20 0.40
GPR55 Q9Y2T6 1/20 0.40
ALDH1A1 P00352 4/20 0.39
BCL2 P10415 1/20 0.39
HPGD P15428 3/20 0.38
REV1 Q9UBZ9 1/20 0.38
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2365933 0.90 HTT (0.40) KMT2AMEN1LMNAHTTSMN1; SMN2
SCHEMBL2366549 0.86 ALDH1A1 (0.44) KMT2AMEN1LMNAHTTSMN1; SMN2
SCHEMBL2366915 0.84 MEN1 (0.45) KMT2AMEN1C1SLMNATSHR
SCHEMBL14686547 0.83 MEN1 (0.44) KMT2AMEN1C1SLMNATSHR
SCHEMBL2366155 0.83 LMNA (0.41) KMT2AMEN1C1SLMNATSHR
SCHEMBL2366612 0.83 MEN1 (0.41) KMT2AMEN1C1SLMNATSHR
SCHEMBL2366604 0.83 MEN1 (0.41) KMT2AMEN1C1SLMNATSHR
SCHEMBL14686883 0.82 MEN1 (0.64) KMT2AMEN1C1SLMNATSHR
SCHEMBL14687647 0.82 MEN1 (0.44) KMT2AMEN1C1SLMNATSHR
SCHEMBL2366199 0.81 KMT2A (0.44) KMT2AMEN1C1SLMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2364975-B1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORP (JP) 2013-06-12 EP disclosed
US-8354401-B2 Oxazolidinone amide aromatic compounds for supressing MMP-9 production MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-01-15 US disclosed
US-8354401-B2 Oxazolidinone amide aromatic compounds for supressing MMP-9 production MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-01-15 US disclosed
US-8354401-B2 Oxazolidinone amide aromatic compounds for supressing MMP-9 production MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-01-15 US disclosed
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-27 US disclosed
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-27 US disclosed
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-27 US disclosed
EP-2364975-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE Mitsubishi Tanabe Pharma Corporation (JP) 2011-09-14 EP disclosed
EP-2364975-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE Mitsubishi Tanabe Pharma Corporation (JP) 2011-09-14 EP disclosed
WO-2010050461-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE 田辺三菱製薬株式会社 (JP) 2010-05-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MMP9, MMP10, MMP2 KMT2A 800/4885MEN1 2896/4885C1S 3294/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.